@article{grammens_threedimensional_2024,
	title = {Three‐dimensional bone morphology is a risk factor for medial postmeniscectomy syndrome: A retrospective cohort study},
	volume = {11},
	issn = {2197-1153, 2197-1153},
	url = {https://esskajournals.onlinelibrary.wiley.com/doi/10.1002/jeo2.12090},
	doi = {10.1002/jeo2.12090},
	shorttitle = {Three‐dimensional bone morphology is a risk factor for medial postmeniscectomy syndrome},
	abstract = {Abstract
            
              Purpose
              The study aims to identify differences in tibiofemoral joint morphology between responders (R group, no pain) to arthroscopic partial medial meniscectomy ({APMM}) versus medial postmeniscectomy syndrome patients ({MPMS} group, recurrent pain at 2 years postmeniscectomy) in a clinically neutrally aligned patient population. The second aim was to build a morphology‐based predictive algorithm for response to treatment ({RTT}) in {APMM}.
            
            
              Methods
              Two patient groups were identified from a large multicentre database of meniscectomy patients at 2 years of follow‐up: the R group included 120 patients with a {KOOS} pain score {\textgreater} 75, and the {MPMS} group included 120 patients with a {KOOS} pain score ≤ 75. Statistical shape models ({SSMs}) of distal femur, proximal tibia and tibiofemoral joint were used to compare knee morphology. Finally, a predictive model was developed to predict {RTT}, with the {SSM}‐derived morphologic variables as predictors.
            
            
              Results
              No differences were found between the R and {MPMS} groups for patient age, sex, height, weight or cartilage status. Knees in the {MPMS} group were significantly smaller, had a wider femoral notch and a smaller medial femoral condyle. A morphology‐based predictive model was able to predict {MPMS} at 2 years follow‐up with a sensitivity of 74.9\% (95\% confidence interval [{CI}]: 74.4\%–75.4\%) and a specificity of 81.0\% (95\% {CI}: 80.6\%–81.5\%).
            
            
              Conclusion
              A smaller tibiofemoral joint, a wider intercondylar notch and smaller medial femoral condyle were observed shape variations related to medial postmeniscectomy syndrome. These promising results are a first step towards a knee morphology‐based clinical decision support tool for meniscus treatment.
            
            
              Study Design
              Case–control study.
            
            
              Level of Evidence
              Level {IIIb}.},
	pages = {e12090},
	number = {3},
	journaltitle = {Journal of Experimental Orthopaedics},
	shortjournal = {J. exp. orthop.},
	author = {Grammens, Jonas and Van Haver, Annemieke and Danckaers, Femke and Vuylsteke, Kristien and Sijbers, Jan and Mahluf, Lotem and Angele, Peter and Kon, Elizaveta and Verdonk, Peter and {MEFISTO WP1 Group}},
	urldate = {2024-12-04},
	date = {2024-07},
	langid = {english},
}